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Dual GLP-1/GIP agonists like Tirzepatide leverage both hormones for better metabolic regulation

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Comparative receptor selectivity work pairing semaglutide against tirzepatide (dual GLP-1R/GIPR) and retatrutide (triple GLP-1R/GIPR/GCGR) to isolate the contribution of single-receptor agonism in cell-based reporter assays