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Furthermore, a review of the FDA Adverse Event Reporting System (FAERS) data lists allodynia among the top 50 adverse reactions reported with tirzepatide

These effects can be distressing, even if not always described as nausea

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DB enhances insulin release through mechanisms involving KATP channels, bitter taste receptor signaling, and intraislet GLP-1 secretion

Each medication works differently, and the right choice depends on your health history, goals, and provider recommendations