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Over-loss and muscle pooled SURMOUNT, BMI below 22 reached by about 7% (as early as week 12), toward about 15% by week 88 in the longest trial, clinical underweight under 0.4% (Almandoz 2026)

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Participants adherent to tirzepatide treatment and achieving 5% weight loss by primary endpoint (week 72 SURMOUNT1

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Many people prefer the abdomen for this reason

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Any rapid weight loss, including weight loss from a GLP-1 medication, can include some loss of muscle as well as fat

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Paediatric populations: Tirzepatide is not licensed for use below the age of 18 years

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Once past the BUD, potency cannot be guaranteed

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