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Long interested in Holst's work, in 1990 Novo Nordisk recruited his colleague Schwartz to develop small molecules able to activate the GLP receptor in the pancreas (Molteni, Chen)
Poor glycemic control, hypothyroidism, prior gastric or bariatric surgery, and concurrent use of medications that affect gastric motility (such as opioids, anticholinergics, or cannabis) may also amplify risk
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Structural pharmacology and mechanisms of GLP-1R signaling
10.1056/NEJMoa2032183 [DOI] [PubMed] [Google Scholar] 30
The STEP 1 extension data showed maintained weight loss at 104 weeks, with participants maintaining an average 13.7% weight reduction from baseline
