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Because we included adults aged 18 to 65 years without other chronic diseases, the results may not be generalizable to patients with diabetes or older individuals (ie, populations at increased risk of bone fractures)

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Most common adverse reactions for Wegovy (semaglutide) The most common adverse reactions for Wegovy (incidence 5%) are nausea, diarrhea, vomiting, constipation, abdominal pain, dysesthesia, headache, fatigue, dyspepsia, dizziness, abdominal distension, eructation, hypoglycemia in patients with type 2 diabetes, flatulence, gastroenteritis, gastroesophageal reflux disease, and hair loss

Women with contraindications or those preferring non-hormonal options may benefit from paroxetine, fezolinetant, or off-label SSRIs/SNRIs

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So it is likely some men may need Ed treatments like sildenafil to help even while taking a GLP-1