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References 1 NauckMAHombergerESiegelEGAllenRCEatonRPEbertRet al
GPR40 is primarily expressed by the pancreatic -cells, where it plays a pivotal role in FFA-mediated insulin secretion (249) but also in -cells (250), CCK (251), and GLP-1 (248, 252, 253)
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By modulating dopamine and glutamate signaling, GLP-1 agonists may reduce the rewarding pull of palatable foods, making intrusive thoughts less intense
The medication works primarily by mimicking the naturally occurring GLP-1 hormone, which enhances insulin secretion, suppresses glucagon release, slows gastric emptying, and reduces appetite through central nervous system pathways
