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Because Medicare patients often face overlapping risks such as chronic kidney disease and cardiovascular complications, multi-indication agents such as the SGLT2s remain an important complementary option alongside GLP1s
The authors connect this to something known as the rate hypothesis in addiction research: the faster a substance hits the brain, the stronger and more rewarding it feels

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Collectively, SGLT2i-GLP-1RA combination therapy significantly improved BP control, independent of the order in which the agents were initiated.
