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Physical Activity: Regular exercise complements the appetite-suppressing effects of GLP-1 agonists

Evidence synthesis: We integrate RCT evidence on weight and metabolic outcomes with exploratory findings on reproductive outcomes, highlighting key effect modifiers (baseline obesity/IR phenotype, concomitant metformin, and follow-up window)

Discontinuation might be a factor limiting neuroprotective benefits of GLP1 receptor agonists

In bone, GIP promotes bone formation while GLP-1 inhibits bone absorption

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Lilly cash-pay programs starting at $349-499/month Insurance coverage: Generally better for diabetes indication than weight loss indication Prior authorization typically required Coverage varies widely between plans Compounded options: Compounded semaglutide: $199/month through TrimRx Compounded tirzepatide: $349/month through TrimRx For detailed cost information, see our guides on Ozempic insurance coverage and compounded semaglutide costs