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This paper reviews the physiological, pharmacologic, and clinical foundations linking GLP-1 RA therapy to reproductive outcomes

GLP-1 agonist medications, known by the brand names Ozempic, Trulicity and Wegovy, have proved to be effective for weight loss as well as managing Type 2 diabetes

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Methods Using data from participants with available samples from Phase 2 trials of orforglipron in participants with T2D (N = 361) or with overweight or obesity without diabetes mellitus (N = 234), we performed an exploratory analysis of changes in CV risk markers

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This research was published in Cell Metabolism .