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21 :110-112 Key words: diabetes, cardiovascular outcome trial, semaglutide Licensing requirements for new antidiabetic drugs changed in the USA following the rosiglitazone controversy, and between 2008 and 2020 a dedicated randomised controlled cardiovascular outcome trial (CVOT) was usually required either before or after licensing

Most complications affect the major organ systems but can cause other issues such as hypothermia, hypotension, and bradycardia

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As a result, fecaliths are formed, which cause blockage of the appendix

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As such, its important that weight-loss medication is used as part of a broader approach to healthy weight management, including access to appropriate nutrition, physical activity and behavioural support. Naveed Sattar, a professor of cardiometabolic medicine at the University of Glasgow, said: Expanding the range of effective treatments is important in helping people sustainably reduce caloric intakes within an increasingly obesogenic environment