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These pathological changes result in mucus layer thinning and elevated permeability, substantially compromising barrier function and increasing intestinal epithelial vulnerability to pathogenic invasion and harmful stimuli [37]

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This effect was mediated through the release of -endorphin rather than suppression of proinflammatory cytokine expression in spinal microglia [31] (Fig

[DOI] [PMC free article] [PubMed] [Google Scholar] 24.Bouchi R., Nakano Y., Fukuda T., Takeuchi T., Murakami M., Minami I., Izumiyama H., Hashimoto K., Yoshimoto T., Ogawa Y