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2017: the FDA approved semaglutide (Ozempic) for type 2 diabetes the once-weekly molecule that would change everything, with greater A1c reduction and weight loss than its predecessors in the SUSTAIN trial program
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The uptake of liraglutide and semaglutide into selected brain areas is similar but not fully identical (eg, semaglutide had a distribution extending more laterally and into posterior portions of the nucleus arcuatus) [19]
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It is largely related to rapid weight loss , especially when 20-30% of body weight is lost in a short period of time
