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Zepbound has a GLP-1 receptor agonist and a GIP stimulant

5,8 Recent data from an observational Japanese study of oral semaglutide users found that sleeping more than six hours per night and improving sleep quality during treatment were independently associated with greater odds of achieving at least 3 percent weight loss, whereas severe stress, late-night dinner after 9 pm, and sleeping within three hours of dinner were linked with poorer weight loss outcomes

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Zou X, Huang Q, Luo Y, et al

Some practitioners use a strategy of reaching target weight with full-dose GLP-1, then gradually reducing to a GLP-1 maintenance dose while continuing HRT

Dulaglutide and cardiovascular outcomes in type 2 diabetes (REWIND): a double-blind, randomised place-bo-controlled trial