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Mechanisms mediating the diuretic and natriuretic actions of the incretin hormone glucagon-like peptide-1

Tyr1 and Ile7 of glucose-dependent insulinotropic polypeptide (GIP) confer differential ligand selectivity toward GIP and glucagon-like peptide-1 receptors

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Molecular and Cellular Biology

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Under physiological conditions, most studies report no meaningful cross-reactivity among the peptide ligands and the receptors of this family [359,360]