how long to feel effects of glp 1 What are GLP-1s? GLP-1 receptor agonists | How

Reduces appetite aids weight loss Common Drugs (Examples) Exenatide Liraglutide Dulaglutide Semaglutide Lixisenatide Clinical Uses Type 2 Diabetes Mellitus (as monotherapy or combination) Obesity / weight management (especially semaglutide, liraglutide) Cardiovascular benefit: reduces major adverse CV events in T2DM with CVD Administration Subcutaneous injection (daily or weekly depending on formulation) Oral semaglutide available for some patients Adverse Effects Gastrointestinal: nausea, vomiting, diarrhea Risk of pancreatitis (rare but serious) Mild hypoglycemia if combined with sulfonylureas or insulin Injection site reactions Contraindications / Precautions Personal/family history of medullary thyroid carcinoma History of multiple endocrine neoplasia syndrome type 2 (MEN2) Severe gastrointestinal disease (gastroparesis) GLP-1 agonists = incretin mimetics

Clinical trials of GLP-1 receptor agonists have shown average reductions in daily energy intake of roughly 2030% during early treatment phases , reflecting the combined effects of increased satiety and reduced food preoccupation

doi: 10.1002/jbm4.10209 61 MaXMengJJiaMBiLZhouYWangYet al

Outlook Depending on the molecule (native or recombinant long-acting) and the route of administration, GLP-1 analogs have broad pleiotropic action on metabolism

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Obesity and Nonalcoholic Fatty Liver Disease: Biochemical, Metabolic, and Clinical Implications