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Retatrutide titration schedule from the Phase 2 trial: 2mg starting dose escalating to 12mg every 4 weeks, plus a 6-week slow protocol for nausea-prone users

Retatrutide works by influencing three key hormone receptors involved in these processes

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Semaglutide 2.4mg once weekly, a subcutaneously administered GLP-1 RA approved for obesity treatment in 2021, results in 1517% mean weight loss (WL) with evidence of cardioprotection