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There is a legitimate oral alternative, however: The FDA approved Rybelsus, a semaglutide tablet for type 2 diabetics, in 2019

They help people lose weight by working in both the gut and the brain, acting on digestion, insulin and appetite, helping quiet cravings and what users describe as food noise. So named for the GLP-1 hormone they mimic, the medicines have also shown success in cardiovascular disease, heart failure, sleep apnea and kidney disease

In October, Found Health and Hims & Hers entered the fray

The STEP 1 trial revealed that semaglutide led to greater reduction in fat mass than lean body mass, consistent with other weight loss interventions

The redness and swelling usually disappear within a few hours

Market Trend Report Employer Approaches to GLP-1 Coverage December 15, 2025 PHTI For employers, glucagon-like peptide-1 receptor agonists (GLP-1s) for obesity represent an unprecedented healthcare challenge