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Consequently, GLP-1 that is secreted by intestinal L-cells is rapidly degraded by dipeptylpeptidase-4 (DPP-4) in the endothelium of the portal circulation and in the liver, as well as by a soluble circulating moiety of DPP-4

muciniphila are interesting candidates as they can potentially reach and interact with the epithelial barrier

The key takeaway

Summary Integrating emerging mechanistic and clinical observations, this review synthesizes current evidence from a metabolic flux perspective

Originally designed to treat diabetes and support weight loss, GLP-1 medications...

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