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Here, we investigated the effects of GLP-1 conjugated to estradiol (GE2) on metabolism, cognition, inflammation and neurogenesis in the hippocampus of middle-aged male and female rats fed a standard (SD) or Western (WD) diet
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Tirzepatide's dual effects on GLP-1 and GIP may explain its superior performance.
Tirzepatide, a dual GLP-1/GIP receptor agonist has been approved for glycaemic control in type 2 diabetes as well as for obesity management leading in up to 22.5% WL in phase 3 obesity trials
