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However, the mucosal delivery of this spray also faces predicaments such as low bioavailability, mucosal barrier limitations, drug stability issues, and patient acceptance

RiskBenefit Assessment and Pharmacovigilance Needs Given the widespread use of GLP-1RAs and other incretin-based agents for obesity and T2D, comprehensive evaluation of even common GI adverse effects remains limited

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However, this convenience comes with a markup over the underlying compounding cost

Patients starting on a slightly higher dose (5 mg or more) may see earlier weight changes compared to those beginning at the introductory 2.5 mg dose

doi: 10.1097/HJH.0000000000002216