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It is also worth noting that while Retatrutide is being studied in clinical trials, it is not approved for medical or human use outside of controlled investigations

JAMA Neurology 2019

Adipose tissue plays a major role in peripheral androgen generation (40), and increased intra-adipose androgen activation is observed even in women with simple obesity (41)

Its impact on diabetes, particularly in improving insulin sensitivity, is crucial because impaired brain insulin signaling heightens the risk of neurodegenerative disorders, thus showing neuroprotective benefits beyond metabolic regulation [55]