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Indeed other gut hormones such as GIP must be responsible for the incretin effect to a higher degree than once thought

Most patients starting semaglutide notice appetite suppression within the first 3-5 days of injection, yet the scale often remains unchanged for 2-3 weeks

[DOI] [PubMed] [Google Scholar] 18.Christensen R, Kristensen PK, Bartels EM, et al

Fiber bulks up the stool and makes it easier to pass through the intestines, so there's less effort required to have a bowel movement

Understanding these causes is crucial for managing side effects effectively

This allows for once a week dosing, like other newer GLP-1s