surmount trial tirzepatide Delivers in SURMOUNT-2 SURMOUNT-2: Tirzepatide confers about 15%
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It also appears to modulate the gastrointestinal side effects of GLP-1 activation, which may explain why tirzepatide is better tolerated despite being more potent

By stimulating these receptors, tirzepatide enhances insulin secretion when blood sugar levels rise

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Trial SURPASS-1 (Lancet 2021) Population 478 adults with T2D, monotherapy vs placebo
