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International Journal of Food Science, 2019 , 4138534

[26] have speculated long-term GIP receptor agonism results in significant GIP receptor downregulation and effectively leads to GIP receptor antagonism with the effect of reduced food intake

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The ability of the MD to reduce visceral adiposity while preserving LBM may have important implications in the context of semaglutide therapy, which is known to reduce overall fat but, in some rare cases, also to associate with a LBM loss [68, 69]