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Description

This study aims to comprehensively review the impact of GLP-1 RAs on various body systems, emphasizing both positive and negative effects while addressing existing knowledge gaps in the literature

Results Patients with a high cumulative dose of GLP-1 agonist are associated with a higher risk of developing drug-induced pancreatitis associated with GLP-1 agonists, indicated by a statistically significant odds ratio

Key pathways, including Wnt/-catenin, bone morphogenetic protein 2/Smad, phosphoinositide 3-kinase/Akt and protein kinase A, play a role in this

Additionally, these are not components of FDA-approved drugs and have not been found safe and effective for any condition.At this time, these drugs are only legally accessible to clinical trial patients

For drugs with a narrow therapeutic index, other factors need to be monitored closely, including plasma drug levels, patients clinical outcomes, and laboratory markers