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Zepbound is used along with a reduced-calorie diet and increased physical activity for chronic weight management in adults with obesity or with overweight plus a weight-related condition

Patients with a history of depression or suicidal thoughts should be monitored closely, and those experiencing persistent severe nausea or vomiting should be evaluated for gastroparesis

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Why Some Patients Report Mood Changes on GLP-1 Therapy Semaglutide works by stimulating GLP-1 receptors throughout the body and brain