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If a medication helps a person lose weight and they stop the medication, the basic biology regulating weight has not changed, and weight will be regained, Bessesen says

A review of recent literature reveals a consistent pattern: patients on semaglutide present with nausea, vomiting, abdominal pain, or early satiety, often in the absence of other identifiable causes

GLP-1 receptor agonists (semaglutide, dulaglutide, liraglutide) work by mimicking a natural hormone that regulates blood glucose and appetite
Nausea, vomiting, diarrhea, and constipation are reported frequently, especially in the early weeks