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Some observational studies of patients with type 2 diabetes suggest that GLP-1 receptor agonist use associates with reduced dementia risk compared with other glucose-lowering medications, but these findings require cautious interpretation due to potential confounding factors

The FDA also found no elevated risk of other psychiatric side effects, such as psychosis, irritability, anxiety or depression

Studies on mice indicated that this could be countered by introducing bacteria into the gut that have the opposite effect, such as Lactobacillus rhamnosus , Lactobacillus acidophilus , and Bifidobacterium bifidum