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In other pre-clinical experiments, GLP-1 analogs have been utilized to selectively deliver nuclear hormone payloads to cells in a targeted manner

Furthermore, Retatrutide substantially enhanced liver function, reduced triglyceride levels, cholesterol levels

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Further, PPG+ neurons do not express GLP-1R, and their action is unaffected by peripheral administration of GLP-1R agonists (Trapp and Brierley, 2022)