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Retatrutide has the highest overall adverse event burden, primarily because of the dysesthesia issue
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Besides, akin to GLP1, GIP demonstrates a glucosedependent effect on insulin secretion [127], implying that GIP could function in the antihyperglycemic effect of DPP4i
The demand for the drugs has outpaced supply, leading to shortages, leaving some Type-2 diabetes patients without necessary medication
In adults with overweight or obesity and cardiovascular disease, but without diabetes, semaglutide reduced major adverse cardiovascular events at a mean of 40 months [32] [33]
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