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The cardiovascular outcome trials for the new obesity pharmacotherapies will help us understand better the long-term benefits and risks with each molecule

These agents act on multiple physiological pathways involved in type 2 diabetes with the effect of increasing insulin secretion and decreasing glucagon to control glucose levels (1,2)

JAHA 12 , e029282 (2023)

Some reports also conclude potential improvements in body composition, including lean mass

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Proper dosing schedules become essential because higher doses lead to more frequent side effects such as gastrointestinal upset, and the side effects can be managed by using the minimum effective dose or slow titration (Figure 2)