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Tirzepatide: Side effects and safety Tirzepatide can sometimes cause some uncomfortable side effects, and digestive issues like nausea, diarrhea, vomiting, constipation, or stomach discomfort are the most common

Mayo Clin Proc

Maximum dose The maximum Zepbound dosage is 15 mg once weekly

Pyridoxine is added to the formulation to counteract these side effects

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