glp 1 agonisten GLP-1 Receptor Agonists and Research to Treat Overeating and Substance Use Disorders Evolution of GLP‐1 Receptor Agonists

The ongoing dedicated ophthalmic trial named as FOCUS study, which aims to evaluate semaglutides long-term effects on diabetic retinopathy, is now ongoing and could contribute to a comprehensive understanding of the true risk-benefit profile of these agents in patients with or at risk for diabetic retinopathy (NCT03811561) [104]

Diab Res

2011;301:F355F363

178,180 The PI3K/Akt signaling pathway, activated by GLP-1, plays a vital role in maintaining pancreatic -cell survival and promoting their proliferation

Limited Long-term Data : While short- to medium-term data are compelling, the long-term safety and efficacy profile over decades of treatment remains incompletely characterized

3 It also promotes proliferation and reduces apoptosis of pancreatic -cells, thereby maintaining their quality and functionality