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The RACGP has been calling for effective obesity-management medication to be subsidised on the Pharmaceutical Benefits Scheme (PBS) to reduce health inequity and remove the cost barrier for many Australians

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However, in the last twenty years drug development targeting the glucagon-like peptide 1 receptor (GLP-1R) has opened a new window of opportunity for reliable, significant medical weight loss at tolerable doses 2 (Figure 1)

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DPP4 serum levels of morbidly obese men are elevated compared with lean controls and significantly correlated with BMI, the size of adipocytes in subcutaneous and visceral fat, and the adipocyte hormones adiponectin (negatively) and leptin