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Key Facts: Full Name : Glucose-dependent insulinotropic polypeptide Also Known As : Gastric inhibitory polypeptide (older term, now less favored) Produced By : K-cells in the proximal small intestine Stimulus for Release : Nutrient ingestion, especially glucose and fat Main Actions : Stimulates insulin secretion (only when glucose is elevated) Influences fat metabolism Modulates energy balance and satiety May impact bone turnover and neuroprotection Where Is GIP Produced

Treatment response : As per NICE guidance, assess response after 6 months and continue only if adequate benefit is demonstrated (HbA1c reduction of at least 11 mmol/mol [1%] and/or 3% weight loss from initial body weight)

We noted a tendency toward an increased number of Fos (+) neurons in the ARH (283.067.8, n =3, for saline injections

This area typically has enough subcutaneous fat to allow for proper absorption

Some show no relationship between the drug and eye disease

Dyslipidaemia, characterised by elevated cholesterol and triglyceride levels or reduced high-density lipoprotein, contributes significantly to atherosclerosis and subsequent cardiovascular events