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The peptide agonist-binding site of the glucagon-like peptide-1 (GLP-1) receptor based on site-directed mutagenesis and knowledge-based modelling

Zhou, Q., Verne, M

GLP-1 (glucagon-like peptide-1) receptor agonists are injectable medications that: Slow digestion to reduce appetite Stimulate insulin production to lower blood sugar Promote weight loss (up to 15% of body weight in some cases) Common brands include: Ozempic (semaglutide) for type 2 diabetes Wegovy (semaglutide) for obesity Mounjaro (tirzepatide) for diabetes and weight loss According to the American Diabetes Association, over 8 million Americans now use GLP-1 drugs-and their foot health impacts are significant

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Similar content being viewed by others Introduction Weight loss can arise in a variety of clinical contexts, including chronic diseases such as anorexia nervosa and inflammatory bowel disease, as well as from active medical interventions like bariatric surgery and pharmacotherapy