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Lancet 372(9645):12401250 Drucker DJ, Sherman SI, Gorelick FS, Bergenstal RM, Sherwin RS, Buse JB (2010) Incretin-based therapies for the treatment of type 2 diabetes: evaluation of the risks and benefits

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--- 7 Contraindications Liver disease Bradyarrhythmia Peptic ulcer disease Severe asthma --- 8 Why It Is Rarely Used Now High incidence of liver toxicity Frequent dosing Need for regular liver monitoring Availability of safer alternatives Tacrine has been discontinued in many countries