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Glucagon receptor-mediated effects introduce additional considerations: Potential for transient increases in heart rate (also observed with GLP-1R agonists) Theoretical risk of hyperglycaemia from glucagon signalling, though phase 2 trial data suggest this is counterbalanced by concurrent GLP-1R and GIPR agonism In phase 2 trials, the most commonly reported adverse events were gastrointestinal in nature, consistent with the class

Consumer complaints worth remembering

C.SpringerW.et al (2020)

Ask about hormonal context: discuss menopausal status, contraceptive use, and pregnancy plans before initiating agents with systemic metabolic effects

Once you puncture the rubber stopper, you've introduced potential contamination

GLP-1 agonists come in 2 forms: Self-injectable medications , supplied in an injection pen