glp-1 positive side effects Frontiers Mechanisms by which GLP-1 agonists

DNA, deoxyribonucleic acid

An accumulating body of studies are showing positive potential for using GLP-1s for substance use, said Christian Hendershot, director of clinical research at the USC Institute for Addiction Science in Los Angeles

GLP-1 RA, GLP-1 receptor agonist

GLP-1R internalizes via an arrestin-independent, GRK-dependent, clathrin- or caveolae-mediated pathway [44]

Screening and data extraction were not performed in duplicate, further increasing risk of selection bias

GLP-1RAs impact gastric, intestinal, and gallbladder motility, which can be beneficial (eg, through slowing glucose and lipid entry into the circulation after meals) but may also increase the risk of adverse consequences (eg, retained gastric contents, potentially resulting in pulmonary aspiration during endoscopy or induction of general anesthesia and gallbladder and biliary complications)