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The choice of this model considered the variation in dosing and study designs, while acknowledging its sensitivity to small-study effects given the wide range of trial sizes included

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doi: 10.3389/fendo.2021.624423 142

Unlike prior reviews that were limited by fewer studies, mixed designs, or inconclusive results, our analysis focuses exclusively on high-quality RCT data

The structure of glp 1 programs ensures consistency while still allowing flexibility
Mortality was captured in all analyses as a result of diabetes-related complications (based on UKPDS Outcomes Model 2 data) and background mortality based on UK-specific, cause-subtracted life tables published by the World Health Organization [18, 22, 23]
