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In summary, this investigation has unveiled the existence of a newly characterised inter-organelle signalling hub in pancreatic -cells which involves active endosomal GLP-1R localisation to ERMCSs via VAPB binding and engagement of the AKAP SPHKAP to enable ERMCS-restricted cAMP/PKA activity via the assembly of PKA-RI biomolecular condensates, leading to PKA phosphorylation of the MICOS complex, enhanced mitochondrial remodelling and improved mitochondrial function, with important implications for the modulation of -cell function and survival and the potential to serve as a mechanism for GLP-1R-induced mitochondrial adaptation during metabolic stress and excess nutrient exposure

Ozempic has been studied for its effectiveness in managing type 2 diabetes

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In this study, we identified a neural circuit in male mice that compensates for the reduction in the number of glutamatergic neurons in the BLA due to heroin dependence, extending from the NTS to the BLA

This heat treatment in the SDS containing sample buffer interrupts the pentameric interaction of phospholamban monomers

Personalized risk stratification would be made possible by the identification of clinical or genetic elements causing GLP-1RA-associated vestibular diseases