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In the SURPASS-2 head-to-head against semaglutide for diabetes, tirzepatide produced significantly greater A1c reductions

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This suggests the triple receptor mechanism does not dramatically worsen constipation compared to single or dual receptor approaches

However, rotating injection sites helps avoid a build-up of scar tissue, which can interfere with the medication

doi: 10.1095/biolreprod.115.137539 164 SunZLiPWangXLaiSQiuHChenZet al

Further, active forms of GLP-1, as well as inactive metabolites, are rapidly eliminated by the kidneys ( The short half-life of endogenous GLP-1 has led to the development of GLP-1 receptor agonists (GLP-1RAs) and DPP-4 inhibitors as therapeutic strategies to extend the duration of GLP-1 action in the treatment of type 2 diabetes ( GLP-1 receptor agonists The first approved GLP-1 receptor agonist (GLP-1 RA) was exenatide in the United States of America (USA) in 2005 and in Europe one year later