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Physiology and Emerging Biochemistry of the Glucagon-Like Peptide-1 Receptor
Additionally, fasting blood glucose and glucagon decreased, glucose tolerance improved and insulin concentrations increased in response to exenatide
Retatrutide adds glucagon receptor activation to the mix, which drives additional lipolysis and energy expenditure beyond what GLP-1 and GIP agonism provide alone
GLP-1RA has also been reported to promote motor activity and energy expenditure, thus activating the metabolism of brown fat in rodents (20)
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