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For all outcomes, we extracted data for the modified intention-to-treat population, defined as all randomly assigned participants who received a least one dose of the study drug

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Reductions in total daily insulin dose may largely track with declining adiposity and improved insulin sensitivity, but they could also reflect changes in food intake, clinical attention, and proactive dose adjustments

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Activation of GIP and GLP-1 receptors can initiate intracellular cyclic AMP signaling cascades and downstream regulatory pathways involved in cellular metabolic activity