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Researchers found that men on semaglutide had a higher risk of developing erectile dysfunction (ED) and testosterone deficiency compared to those not using the drug

Additionally, there is observed enrichment of hypercalcemia (STC1, GAST, PTHLH), urticaria (severe eczema) (NPS, CYSLTR2, TAC1), and secretion of hydrochloric acid in parietal cells (CCKBR, GAST)

For women, especially those with underlying hormonal conditions like polycystic ovary syndrome (PCOS), even small shifts in insulin levels, body weight, or inflammation can have a ripple effect on oestrogen balance, ovulation patterns, and menstrual symptoms

When activated, GLP-1 receptors trigger a cascade that slows stomach emptying, lengthens the time food takes to leave the gut, boosts insulin release in response to glucose, and reduces appetite signals in the hypothalamus

Sermorelin + GLP-1: Body Composition Evidence Getting Stronger Evidence level: Established GH research + growing clinic protocols

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