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Learn the metabolic reasons, trial data, and evidence-based next steps.

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We also discuss combination therapies and strategies to mitigate muscle mass loss during treatment and calls for targeted research, improved clinical education, and policy reforms to optimize the translational potential of GLP-1R agonists in both individualized care and population health

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GLP-1RAs reduce events linked to atherogenic cardiovascular disease (especially ischemic stroke) and also renal outcomes (FLOW trial with semaglutide), with a limited effect on heart failure

Metabolic syndrome is characterized by obesity, insulin resistance, dyslipidemia, and hypertension