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Available from Accessed 18 August 2022 41

Tiered Model: Month 1-2 (2.5-5 mg): Pay: $299/month Looks like great deal Month 6-12+ (12.5-15 mg): Pay: $499/month Total cost often higher than flat-rate Less predictable Why Providers Choose Flat-Rate: Patient preference for simplicity Easier to administer Better retention (no price shock) Fair overall pricing Competitive advantage Cost Comparison Example: 18-Month Treatment Flat-Rate ($349/month): Months 1-18: $349/month Total: $6,282 Tiered Pricing Example: Months 1-2 (2.5-5 mg): $299/month = $598 Months 3-6 (7.5-10 mg): $399/month = $1,596 Months 7-18 (12.5-15 mg): $499/month = $5,988 Total: $8,182 Flat-rate saves $1,900 over tiered in this example

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They may include nutrients or botanicals associated with general metabolic support, but they are not drugs, and they are not tested as drug delivery systems

Indeed, Eli Lillys senior vice president (SVP) of neurodegeneration research, Andrew Adams, said in June 2023 that the company was closely monitoring the updates from patients related to addiction, but cautioned that human studies would be difficult to run given that they often have high variability resulting from self-reported outcomes