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HDL cholesterol modestly increased across the dose range, while LDL cholesterol showed minimal change a pattern consistent with weight-mediated lipid improvements rather than direct drug effects on LDL pathways

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Persistent hunger throughout the day, no change in food noise or cravings, and no weight loss after 4 or more weeks on a stable dose all suggest the dose is too low or absorption is insufficient

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The slices were bathed in oxygenated aCSF (3234 C) at a flow rate of ~2 ml min 1

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