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It typically results from inadequate insulin secretion because of dysfunction of the insulin-secreting pancreatic beta cells

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Maintenance is measured in months and years

Known countermeasures to weight loss-associated bone loss include dietary factors, ensuring adequate protein, calcium, and vitamin D, along with participating in progressive resistance training (RT) to support skeletal muscle health and maintain long-term weight loss (Beavers et al., 2024)

Therefore, it is accepted that glucagon may affect energy expenditure via BAT-independent mechanisms (for review see [60, 61])

Pediatr Rev