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Tolerability: It avoids the higher incidence of heart rate spikes and severe GI distress seen at the 12 mg maximum dose

Eventually, the optic disc edema resolved, leaving residual structural damage i.e., GCL atrophy, consistent with the typical presentation of NAION

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Conversely, variants associated with lower baseline receptor sensitivity may require higher doses or progression to dual-mechanism compounds like tirzepatide

Nevertheless, the literature lists the disorder among those in which the KD is absolutely contraindicated [68,99,100]